Difference between revisions of "Sodium thiosulfate"

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==Uses==
 
==Uses==
 
===Primary===
 
===Primary===

Latest revision as of 21:45, 26 March 2020

 
Sodium thiosulfate
Chemical formula Na2S2O3
OTP appearance white crystals 
Molar Mass(g/mol) 158.11 
Melting Point(°C) 48.3 
Boiling Point(°C) 100 
Density(g/cc) 1.667 
Solubility in water(g/L) 701 
Solubility in ethanol(g/L) non
NFPA 704
NFPA704.png
0
1
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Uses

Primary

  • Pharm: WHO LEM cyanide antidote (also hydroxocobalamin) Can be delivered by IM injection in the treatment of cyanide poisoning.[1]

Secondary

  • Iodometry (2 Na2S2O3 + I2 Na2S4O6 + 2 NaI // Converts elemental iodine to ionic iodine, clearing the solution)
  • Neutralization of halide compounds
  • Cooling slurry with water

Natural occurrence

Hazards

Production

Synthesis

Direct

  1. Boil a solution of sodium hydroxide with sulfur in the correct stochiometric ration, producing (less soluble, 180g/L) sodium sulfide and (very soluble, 701g/L) sodium thiosulfate.
    6 NaOH(aq) + 4 S
    {
    100°C}
    2 Na2S + Na2S2O3 + 3 H2O
  2. The sulfide biproduct can be converted to thiosulfate as well by combination with sulfur dioxide, recovering some of the initial sulfur.
    2 Na2S + 3 SO2 2 Na2S2O3 + S

via sodium sulfite

Add sulfur to a solution of sodium sulfite

Na2SO3 + S Na2S2O3

Testing

Purification

Storage

Disposal

See Also

References

  1. Bebarta, Vikhyat S.; Brittain, Matthew; Chan, Adriano; Garrett, Norma; et al (2017) "Sodium Nitrite and Sodium Thiosulfate Are Effective Against Acute Cyanide Poisoning When Administered by Intramuscular Injection"
    Annals of Emergency Medicine 69(6); pp718-725.. 
    link courtesy Elsevier.