Folic acid

 

Folic acid
aka Vitamin B₉

Chemical formula	C19H19N7O6
Molar Mass(g/mol)	441.40
Density(g/cc)	1.6±0.1
Melting Point(°C)	250 (decomp)
Solubility in water(g/L)	0.0016
NFPA 704	0 0 0

Related to dihydrofolic acid, tetrahydrofolic acid, folic acid is converted to folate in the liver.

Uses

Primary

• Pharm: WHO LEM vitamin/mineral

Natural occurrence

• Does occur naturally in leafy green vegetables and as a secondary metabolite of many monads.

Production

Extraction

• Mitchell, Herschel K.; Snell, Esmond E.; Williams, Roger J. (1944) "Folic Acid. I. Concentration from Spinach"
  J. Am. Chem. Soc., 66(2); pp267–268. 
  DOI:DOI: 10.1021/ja01230a032
  link courtesy ACS.

Synthesis

• US patent 2487393 "Process for the manufacture of folic acid"
  Link courtesy Google

Purification

• US patent 2694710 "Method for purifying raw folic acid"
  Link courtesy Google

See Also

• US patent 5968788 "Method for producing folic acid"
  Link courtesy Google
• Greene, Richard (1949) "The extraction of Folic (Pteroylglutamic) acid conjugate from yeast"
  Journal of Biological Chemistry 179(3) 
  link courtesy Journal of Biological Chemistry.