Bupivacaine

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Bupivacaine
Chemical formula C18H28N2O
Molar Mass(g/mol) 288.43 
Melting Point(°C) 107-108°C
NFPA 704
NFPA704.png
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Uses

Primary

  • Pharm: WHO LEM local anesthetics

Natural occurrence

Hazards

Production

Extraction

Synthesis

  • See patent WO 2009089842A1[1]
  • See diagram from wikimedia commons[2]
  1. Combine Picolininc acid and ethyl chloroformate in the presence of a base
  2. Add 2,6-Xylidine
  3. Add N-butyl iodide
  4. Reduce with hydrogen

Testing

Purification

Storage

Disposal

See Also

References

  1. ↑ WO 2009089842A1
    courtesy Google Patents.
  2. ↑ Bupivicain Synthesis
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