Ibuprofen

 

Ibuprofen

Chemical formula	C13H18O
Molar Mass(g/mol)	206.29
Density(g/cc)	1.03
Melting Point(°C)	75
Boiling Point(°C)	157
Solubility in water(g/L)	.021
NFPA 704	0 0 0

Uses

Primary

• Pharm: used in the medication Ibuprofen on the WHO LEM, WHO IEHK, and DHS AMF

Natural occurrence

• Does not occur naturally

Production

Synthesis

• Begins with 2-methylpropylbenzene

Hoerscht

1. Combine 2-methylpropylbenzene with acetic anhydride in the presence of hydrofluoric acid

   C₁₀H₁₄ + (CH₃CO)₂O

   {HF

   →

   }

   C₁₂H₁₆O + CH₃COOH + H₂O

2. Hydrogenate over raney nickel

   C₁₂H₁₆O + H₂

   {Ni

   →

   }

   C₁₂H₁₈O

3. Carbonylate over palladium

   C₁₂H₁₈O + CO

   {Pd

   →

   }

   C₁₃H₁₈O₂

See Also

• acetylsalicylic acid (aspirin)
• paracetamol (tylenol)