Clindamycin

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Revision as of 01:29, 4 December 2024 by Admin (talk | contribs) (Created page with "{{Compound|chemf=C18H33ClN2O5S|struct=Clindamycin.png|group=Bioproducts |complexo=yes||mm=424.98 |medicine=yes|med_class=Antibiotics|listed_who=yes|listed_dhs=yes }} ==Uses== ===Primary=== * Pharm: WHO LEM antibiotic ==Natural occurrence== * '''Does not''' occur naturally ==Hazards== ==Production== ===Synthesis=== * Chlorinate lincomycin using thionyl chloride to replace the 7-hydroxy group with a chlorine atom with inversion of chirality.<ref>{{Cite pub | last1...")
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Clindamycin
Chemical formula C18H33ClN2O5S
Molar Mass(g/mol) 424.98
NFPA 704
NFPA704.png
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Uses

Primary

  • Pharm: WHO LEM antibiotic

Natural occurrence

  • Does not occur naturally

Hazards

Production

Synthesis

  1. Reflux lincomycin with thionyl chloride in carbon tetrachloride giving clindamycin
    C18H34N2O6S + SOCl2
    {CCl4
    →
    77°C}
    C18H33ClN2O5S + HCl + SO2

Testing

Purification

Storage

Disposal

See Also

References

  1. ↑ Birkenmeyer, R. D.; Kagan, F. (1970) "Lincomycin. XI. Synthesis and structure of clindamycin, a potent antibacterial agent".
    Journal of Medicinal Chemistry 13(4); pp616–619. 
    DOI:10.1021/jm00298a007
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