Hydroxocobalamin
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| Chemical formula | C62H89CoN13O15P |
|---|---|
| OTP appearance | dark red crystals |
| Molar Mass(g/mol) | 1346.37 |
| NFPA 704 |  0
0
0
|
Hydroxocobalamin, along with related compounds cyanocobalamin, methylcobalamin, and adenosylcobalamin, represent bioavailable forms of vitamin B12. Cobalamin coordinates five out of six points on the cobalt atom, leaving the sixth for a hydroxy, nitrile, methyl, or andenosine ligand. The ligands are easily exchanged in vivo and in vitro, and metabolism of cyanocobalamin to hydroxocobalamin + thiocyanate in the kidney is the body's primary way of eliminating cyanide compounds.
Uses
Primary
- Pharm: WHO LEM dietary supplement (vitamin B12a) and cyanide antidote
Natural occurrence
- Occurs in most living beings, produced only by monads.
Hazards
Production
Extraction
- Fermentation of streptomyces griseus produces vitamin B12, cyanocobalamin.[1]
- Cyanocobalamin is converted to hydroxocobalamin by reduction with Zn/HCl, (a dark red solution), aeration, neutralization with NaCO3, and recrystallizing from aqueous acetone.[2]
Synthesis
Testing
Purification
Storage
Disposal
See Also
References
- ↑ US patent 2695862 "Process for obtaining vitamin b12"
Link courtesy Google - ↑ US patent 3138583 "Process for the industrial manufacture of hydroxocobalamin"
Link courtesy Google