Cisplatin

 

Cisplatin

Chemical formula	{{#Chem:Pt*2Cl*2NH3}}
Molar Mass(g/mol)	300.01
NFPA 704	0 0 0

Uses

Primary

• Pharm: WHO LEM antineoplastic

Natural occurrence

• Does not occur naturally

Production

Synthesis

1. Combine potassium hydroxide and chloroplatinic acid giving potassium hexachloroplatinate ({{#Chem: K2[PtCl6]}})
2. Reduce the -hexachloroplatinate to potassium tetrachloroplatinate ({{#Chem: K2[PtCl4]}})
3. Combine with excess potassium iodide giving potassium tetraiodidoplatinate ({{#Chem: K2[PtI4]}})
4. Immerse the iodoplatinate in ammonia, giving a a potassium platinum iodine ammonia complex ({{#Chem:K2[Pt*2I*2(NH3)]}})
5. Prepare a solution of silver nitrate and add the complex, producing a poptassium platinum water ammonia complex ({{#Chem:K2[Pt*2(H2O)*2(NH3)2]}})
6. Combine with excess potassium chloride giving cisplatin({{#Chem:Pt*2Cl*2NH3}}) and potassium nitrate

References

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