Cisplatin: Difference between revisions
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(Created page with "{{Compound|struct=Cisplatin.png|chemf=Pt*2Cl*2NH3|mm=300.01|density=|mp=|bp=|sol_aq=|stp_p=|stp_q=|med_class=Platinum Based Antineoplastics|medicine=yes|listed_who=yes}} ==Uses== ===Primary=== * Pharm: WHO LEM antineoplastic ==Natural occurrence== * '''Does not''' occur naturally ==Hazards== ==Production== ===Extraction=== ===Synthesis=== # Combine potassium hydroxide and hexachloroplatinic acid giving '''potassium hexachloroplatinate''' ({{#Chem: K2[PtCl6]}}) #...") |
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===Extraction=== | ===Extraction=== | ||
===Synthesis=== | ===Synthesis=== | ||
# Combine [[potassium hydroxide]] and [[ | # Combine [[potassium hydroxide]] and [[chloroplatinic acid]] giving '''potassium hexachloroplatinate''' ({{#Chem: K2[PtCl6]}}) | ||
# Reduce the -hexachloroplatinate to '''potassium tetrachloroplatinate''' ({{#Chem: K2[PtCl4]}}) | # Reduce the -hexachloroplatinate to '''potassium tetrachloroplatinate''' ({{#Chem: K2[PtCl4]}}) | ||
# Combine with excess [[potassium iodide]] giving '''potassium tetraiodidoplatinate''' ({{#Chem: K2[PtI4]}}) | # Combine with excess [[potassium iodide]] giving '''potassium tetraiodidoplatinate''' ({{#Chem: K2[PtI4]}}) | ||
Latest revision as of 02:18, 5 December 2024
| Chemical formula | Pt•2Cl•2NH3 |
|---|---|
| Molar Mass(g/mol) | 300.01 |
| NFPA 704 |  0
0
0
|
Uses
Primary
- Pharm: WHO LEM antineoplastic
Natural occurrence
- Does not occur naturally
Hazards
Production
Extraction
Synthesis
- Combine potassium hydroxide and chloroplatinic acid giving potassium hexachloroplatinate (K2[PtCl6])
- Reduce the -hexachloroplatinate to potassium tetrachloroplatinate (K2[PtCl4])
- Combine with excess potassium iodide giving potassium tetraiodidoplatinate (K2[PtI4])
- Immerse the iodoplatinate in ammonia, giving a a potassium platinum iodine ammonia complex (K2[Pt•2I•2(NH3)])
- Prepare a solution of silver nitrate and add the complex, producing a poptassium platinum water ammonia complex (K2[Pt•2(H2O)•2(NH3)2])
- Combine with excess potassium chloride giving cisplatin(Pt•2Cl•2NH3) and potassium nitrate