Cisplatin

 

Cisplatin

Chemical formula	Pt•2Cl•2NH3
Molar Mass(g/mol)	300.01
NFPA 704	0 0 0

Uses

Primary

• Pharm: WHO LEM antineoplastic

Natural occurrence

• Does not occur naturally

Production

Synthesis

1. Combine potassium hydroxide and chloroplatinic acid giving potassium hexachloroplatinate (K₂[PtCl₆])
2. Reduce the -hexachloroplatinate to potassium tetrachloroplatinate (K₂[PtCl₄])
3. Combine with excess potassium iodide giving potassium tetraiodidoplatinate (K₂[PtI₄])
4. Immerse the iodoplatinate in ammonia, giving a a potassium platinum iodine ammonia complex (K₂[Pt•2I•2(NH₃)])
5. Prepare a solution of silver nitrate and add the complex, producing a poptassium platinum water ammonia complex (K₂[Pt•2(H₂O)•2(NH₃)₂])
6. Combine with excess potassium chloride giving cisplatin(Pt•2Cl•2NH₃) and potassium nitrate

References

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